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From the soaring peaks of the Andes to the lush expanse of the Amazon, every corner of South America is a realm of epic adventures and jaw dropping scenery. Picture yourself standing on the mystical heights of Machu Picchu, feeling the roar of Iguazu Falls, or marvelling at the moai statues on Easter Island. From the electrifying energy of cities such as Rio de Janeiro and Buenos Aires to the majestic wilderness of Torres del Paine and the salt flats in Bolivia, there is so much to explore in this vast continent.
In this travel guide, we’ve curated 15 of our team’s favourite, must-visit places in South America that will capture your heart and make you want to discover this incredible continent for yourself. And to ensure your journey is as unforgettable as possible, we will be happy to create a bespoke South America multi-centre holiday tailored to your specific interests and preferences.
So join us as we explore 15 of the most incredible destinations in South America…
Salvador, in north-eastern Brazil, is a city brimming with life, where vibrant Afro-Brazilian traditions meet dramatic coastal scenery and captivating historic buildings.
The heart of Salvador is Pelourinho, a UNESCO World Heritage site with cobbled streets lined with colourful buildings and historic churches, such as the São Francisco Church, renowned for its intricate baroque architecture and extensive use of gold-leaf. Pelourinho is also one of the city’s main cultural hotspots where you’ll hear the sounds of Afro-Brazilian music and dance pulsating through the streets. To watch the traditional Candomblé and Capoeira, try to catch a performance from the Balé Folclórico da Bahia dance troupe who regularly perform at their dedicated theatre in Pelourinho.
Another must-see is the historic Fort Santo Antônio da Barra in the Barra district, which overlooks the bay and offers marvellous views. Salvador’s lively markets, such as Mercado Modelo, are perfect for exploring local crafts and tasting traditional cuisine.
The Salt Flats in Bolivia offer some of the most surreal landscapes you’ll possibly ever encounter. At the heart of this stunning scenery is Salar de Uyuni, the world’s largest salt flat. This vast, dazzling expanse of white creates a mirror-like phenomenon after it rains, creating an almost heavenly vision that seems to stretch endlessly into the sky. This is most likely to happen during the rainy season, which typically runs from November to March.
A day trip to Salar de Uyuni usually also includes a visit to other key sites including: The Train Graveyard, where vintage locomotives lie abandoned; Isla Incahuasi, a cactus-covered island in the middle of the salt flats and The Ojos de Sal, where you can observe the natural salt springs and their unique formations.
For a totally unique experience, you can stay in a salt hotel where even the furniture is constructed from blocks of salt!
Valparaíso is a vibrant port city in central Chile, sprawled across 45 hills. It’s renowned for its unique blend of culture with colourful street art, charming cobblestone streets, lively festivals, and historic funiculars.
The city is split into two distinct areas: the bustling lower section by the harbour and the historic upper quarter, which has UNESCO World Heritage status. In El Plan, you’ll find a lively mix of shops, cafes, and restaurants. To explore the hills, you can either climb the steep stairs or ride the traditional ascensores, including the historic Ascensor Concepción, which has been in operation since 1883.
For some of the best of Valparaíso’s vibrant street art, head to Cerro Alegre and Cerro Concepción where you’ll find murals and vibrant graffiti that transform the areas into open-air galleries. For some of the best panoramic views, head to Plaza Bismarck or Mirador Ciudad de Camogli. If you fancy a day by the beach, head to the nearby Viña del Mar which offers golden sands and a bustling seaside atmosphere.
Mendoza is in the heart of Argentina’s premier wine region and surrounded by world-class bodegas. Framed by the snow-capped Andes, the region is not only celebrated for its wine but is also a popular starting point for people looking to explore the surrounding region.
But let’s start with wine…! Mendoza is synonymous with Malbec, and a visit to one of its renowned wineries is a must. Here, you can take a guided tour, learn about the winemaking process, and, of course, enjoy tastings of the region’s signature wines. To match the wine, Mendoza’s culinary scene is also world class, with local specialities such as asado (Argentine barbecue) and locro (a hearty stew).
The city itself is dotted with cultural gems. Stroll through the elegant Plaza España, adorned with Andalusian tilework, or catch a live music or dance performance in the bustling Plaza Independencia, the city’s main square.
For those looking for outdoors adventures, there are many activities on offer in this region, from horseback riding through the vineyards to white-water rafting on the Mendoza River. The nearby Andes also offer fabulous hiking and mountaineering opportunities, including the challenging ascent of Aconcagua, the highest peak in the Western Hemisphere.
Located in Argentina’s Los Glaciares National Park, the Perito Moreno glacier is one of Patagonia’s most impressive natural wonders. Unlike most glaciers, it is not retreating but actually advancing, moving up to 2 metres per day. This movement creates a dramatic display as building-sized chunks of ice break off and crash into the turquoise waters below, sending thunderous echoes through the surrounding mountains.
Stretching 30 km long, 5 km wide, and towering 70 meters above the water, Perito Moreno is huge. Its shimmering blue ice walls create a true spectacle, especially when the sun lights up the glacier. There are various ways to view this spectacle. You can take a boat tour that brings you close to the glacier’s towering ice walls, or you may choose to take a guided walking tours such as ‘Mini Trekking’ and ‘Big Ice’ to allow you to walk on the glacier itself, with options ranging from 1.5 hours to over 3 hours on the ice. Additionally, tours often include time on the extensive network of catwalks and viewing platforms, providing various angles to marvel at the glacier. Most tours depart from El Calafate and include transport and expert tour guides.
Chile’s vibrant capital, Santiago, is nestled in a valley surrounded by the snow-capped Andes and framed by the famous San Cristóbal and Santa Lucía hills. A great way to see the city is via the network of funiculars that offer excellent vantage points for panoramic cityscape views.
The Plaza de Armas is the historic heart of Santiago and features the impressive Catedral Metropolitana and is surrounded by colonial buildings and lively street performers. Nearby, you’ll find the La Moneda Palace, Chile’s presidential palace. This iconic building is not only a symbol of the nation’s political history but also hosts the changing of the guard ceremony – a must-see event.
Take a wander around Bellavista with its artsy vibe, street murals, and eclectic dining options. Also in Bellavista, make sure you visit La Chascona, the former home of poet Pablo Neruda and now a museum. Designed by Neruda himself in collaboration with architect Germán Rodríguez, it’s a colourful, whimsical house that offers a glimpse into his brilliant, creative mind.
Take a cable car up San Cristóbal Hill for panoramic views of Santiago and the Andes and enjoy the peacefulness of its landscaped gardens and the impressive statue of the Virgin Mary at the summit. For more great views of the city, head to the Costanera Centre, South America’s tallest building with a fabulous observation deck that provides great views of the city and mountains.
Santiago also serves as a gateway to Chile’s renowned wine regions, including the Maipo Valley and Santa Rita, just a short drive away – a great option to combine with a trip to this fascinating city.
Lake Titicaca, with its striking blue waters, is the largest lake in South America and located in the Altiplano region of the Andes, straddling the border between Peru and Bolivia. At an impressive 4,000 metres above sea level, it’s set against a picture-perfect backdrop of mountains sprinkled with charming small islands.
One of our favourite places to stay is in Puno, a lively city on the Peruvian side of the lake, where there is a wide range of accommodation with fantastic lake views.
The lake is home to the Uros and Aymara peoples, who live on floating reed islands and travel by using traditional reed boats. You can visit some of these local communities by visiting Taquile and Uros Islands and also witness their traditional craft making.
Located in the southern part of Chilean Patagonia, Torres del Paine National Park is nestled within the Andean mountain range and is famed for its dramatic landscapes and pristine wilderness. The scenery in Torres del Paine National Park is truly magnificent with jagged mountain peaks, expansive glaciers, and pristine lakes.
This park offers some of the best hiking in Patagonia, with famous trails such as the W Trek and the Paine Circuit. Thanks to the well-maintained roads and trails, there are a range of hikes to suit every fitness level, from easy walks to challenging treks. Notable sights include the Cuernos del Paine, two striking granite peaks, and the Glacier Grey, a massive ice field.
In addition to its dramatic scenery, the park features lush forests, sparkling blue lakes, and opportunities to spot local wildlife such as guanacos and condors.
Cuzco, once the heart of the Inca Empire, is perched 3,400 metres (11,000 feet) above sea level in the Andes Mountains. As the gateway to the renowned Inca Trail, Cuzco offers easy access to the archaeological marvel of Sacsayhuamán, just a few miles to the north. The city itself is a blend of Quechua culture, Inca history, and Spanish colonial influences, all set against a stunning Andean backdrop.
Take a stroll through streets lined with traditional clay-tile roofs and cobblestone pavements, where you’ll find beautifully preserved architecture and bustling markets. Highlights include the impressive Catedral de Cuzco, located in the main Plaza de Armas, and the ornate Iglesia de la Compañía de Jesús, renowned for its baroque architecture. The local cuisine, including pollo a la brasa (roasted chicken) and other traditional dishes, is delicious, and there is a lively bar and nightlife scene to enjoy after the sun sets.
Situated more than 2,000 miles from the Chilean mainland, this remote piece of paradise lies in the heart of the Pacific Ocean. It’s a serene and mystical island with a unique blend of Polynesian culture and natural beauty.
Easter island is famed for its mysterious moai statues – the huge stone figures with oversized heads that dot the island and that were created by the Rapa Nui people of Easter Island. The most impressive of the island’s sites is Ahu Tongariki which is a ceremonial platform that features 15 Moai statues lined up in a row. To get a better understanding of how the Moai statues were carved, visit Rano Raraku quarry. Other must-see sights include the volcanic craters of Rano Kau and the Orongo village, with its fantastic views, well-preserved stone houses and petroglyphs depicting birdmen and other symbols. The pace of life on Easter Island is laid-back and relaxed, and after a day of exploring the island’s wonders you can enjoy the beautiful sunsets and traditional Polynesian cuisine.
Visiting the Amazon offers a chance to experience a slice of nature like nowhere else, with dense jungle, elevated canopies, winding rivers, and staggeringly beautiful waterfalls. The Amazon spans several countries in South America, and each country has its own gateways or entry points for exploring this vast and diverse region, with some of the most popular being Manaus in Brazil; Iquitos, in Peru; Quito in Ecuador and Leticia in Colombia.
One of our favourite gateways from which to explore the Amazon is Manaus, in Brazil. Nestled within the Amazon Basin, Manaus provides easy access to a variety of guided tours and excursions into the surrounding wilderness. Whether you opt for a day trip or a more immersive multi-day journey, there are numerous options to choose from.
Boat trips are a popular way of exploring the Amazon and offer the chance to navigate the complex network of rivers and waterways whilst spotting wildlife, visiting remote communities, and experiencing the rainforest from a unique perspective. Other activities available include jungle explorations, swimming under waterfall pools, fishing for piranhas, and hiking or walking through the bridged canopies.
Near Manaus you can also experience the extraordinary sight of the Meeting of the Waters, where the dark Rio Negro meets the sandy-coloured Amazon river. The rivers flow side by side without mixing immediately due to their different temperatures and speeds, creating a fabulous spectacle.
Iguazu Falls straddles the border of Brazil and Argentina and is one of the world’s most impressive waterfall systems. Stretching 2.7 km wide and with heights ranging from 60 to 82 meters, it dwarfs the Niagara Falls in width and rivals Victoria Falls in sheer grandeur. A UNESCO World Heritage Site, its remote location in the Atlantic rainforest adds to its appeal.
The falls are split between Argentina and Brazil, each offering their own unique experience. On the Argentine side, there are walkways that bring you close to the cascades, including the Devil’s Throat, which creates a permanent mist with its 80-metre drop. You can also take a thrilling boat ride that takes you under the falls. From the Brazilian side, you can enjoy panoramic views of the entire system, including a different, dramatic perspective of the Devil’s Throat.
With up to 13,000 cubic meters of water flowing per second during the rainy season, Iguazu Falls is a truly breath-taking sight and a visit from Buenos Aires or Rio de Janeiro is well worth the trip to see this extraordinary natural wonder.
Buenos Aires, with its tango music, delicious food, and European and Latin blend of cultures, is a wonderful place to soak up the culture of Argentina.
A great place to start your exploration of this fascinating city is in La Boca, where Caminito Street bursts with colourful houses, tango dancers, and local artisan shops. History enthusiasts will find Recoleta Cemetery fascinating with its grand mausoleums and intriguing architecture, as well as Retiro which is home to Plaza San Martín – a square full of historic buildings and a central landmark in the city for cultural events. For some shopping, make your way to Palermo with its chic boutiques and cafes.
Buenos Aires is renowned for being the birthplace of tango, and across the city there are plenty of opportunities to experience authentic tango performances, take dance lessons, and enjoy live music. One of the best places to experience a tango show is in San Telmo. This area is full of tango bars and its lively atmosphere allows you to feel the energy and passion of this traditional dance scene first-hand. After all that dancing, you’ll be ready for some food, and there are great places to eat all over the city. If looking for an upscale, scenic place to eat, Puerto Madero offers a range of waterfront restaurants and bars. It’s especially pretty at night, with twinkling lights reflecting off the river.
Rio de Janeiro is a buzzing city where you can immerse yourself in the rhythm of samba, lounge on the sun-soaked beaches, take in the striking views from Sugarloaf Mountain or marvel at the architectural wonder of Christ the Redeemer.
A great starting point is Rio’s beaches with their iconic sands and azure Atlantic coastline. Copacabana has a lively atmosphere and is perfect for people-watching and relaxing. Nearby, Ipanema offers chic boutiques, trendy cafes, and vibrant nightlife. For a more serene beach day, Barra da Tijuca is a hotspot for surfers and offers a quieter, more relaxed vibe with dazzling sunsets, while Leblon offers a sophisticated family-friendly beach experience.
No visit to Rio is complete without witnessing the awe-inspiring Christ the Redeemer statue. The easiest way to reach the statue is by the Corcovado Railway which offers a scenic journey through the Tijuca Forest, the world’s largest urban rainforest, with great views along the way.
The city itself offers a unique mix of colonial buildings and modern architecture, such as the futuristic Metropolitan Cathedral of São Sebastião, designed by Oscar Niemeyer. It’s also a city that lives and breathes culture, from the samba rhythms that echo through the streets to the explosion of colour on display during the Carnaval (carnival) which usually takes place in February.
A must-do in Rio, and a great way to view the city, is to take the cable car ride up Sugarloaf Mountain. With panoramic views of the beaches, bustling streets, and rainforests, the sight is nothing short of magical.
With spectacular views at every turn, Machu Picchu is a bucket-list destination that lives up to the hype – and more. Perched high in the Andes, this UNESCO World Heritage Site is a masterpiece of Incan architecture. Often referred to as the ‘Lost City of the Incas,’ the site was constructed without the use of mortar and with such precision that many of the structures remain standing today. As you explore, you’ll come across the remnants of ancient temples, terraces and intricate stonework.
The surrounding landscape is equally breath-taking, with lush green mountains that tower above the Urubamba River which winds its way through the valley below. When the clouds roll in and cover the ruins in mist, it truly feels like you’ve stepped into another world.
There are different trails of varying lengths, but for many, the ultimate experience is the 26-mile Classic Inca Trail. This trek is not for the faint-hearted, but if you are brave enough you will be rewarded with some of the most stunning landscapes on the planet. If the full trek sounds too daunting, a day trip by rail is a great alternative. On arrival via train in Aguas Calientes, you can take a bus or taxi up to Machu Picchu and from there explore the site, including the Temple of the Sun, the Sacred Rock, and the Sun Gate, without the strenuous physical effort to get there.
For those looking for an even greater challenge, the steep ascent of Huayna Picchu is a must. The one-hour climb is tough, but the panoramic views and photo opportunities from the top are legendary. From here, you can capture the perfect shot of Machu Picchu, with its cascading terraces spilling down the mountainside – a view that is nothing short of incredible.
Whichever destination or destinations you choose to explore on your South American adventure, one thing is for certain – you’ll have a totally unique experience. If you’re thinking about exploring this special part of the world, we’d love to share our travel expertise with you and craft a multi-centre tailor-made holiday that suits your exact requirements – so please get in touch. We’d love to chat!
Inspired by the guide? We’ve handpicked a few holidays that bring it to life—perfect for turning travel ideas into reality.
